Decision guide
Hyperthermic intraperitoneal chemotherapy (HIPEC) delivers heated chemotherapy directly into the abdominal cavity.
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Hyperthermic intraperitoneal chemotherapy (HIPEC) delivers heated chemotherapy directly into the abdominal cavity. It is studied alongside cytoreductive surgery, an operation to remove tumour tissue. The choice is not simply whether to have surgery, but whether adding HIPEC is appropriate for the particular cancer and treatment stage. Drug regimens, temperature settings and timing vary between approaches.
The role of HIPEC differs by cancer type. A 2025 comparison of national guidelines found the strongest agreement for combining it with surgery in pseudomyxoma peritonei and peritoneal mesothelioma, diseases affecting the lining of the abdomen. Recommendations were divided for colorectal cancer and newly diagnosed ovarian cancer; many guidelines advised against HIPEC for recurrent ovarian cancer and gastric cancer.
For advanced ovarian cancer, one studied choice is tumour-removing surgery with or without HIPEC after chemotherapy given before the operation. A 2022 review of randomized trials found a five-year survival benefit in this treatment setting, but not for surgery without prior chemotherapy or for recurrent disease. This distinction matters: evidence for adding HIPEC at one stage of treatment does not establish its benefit at another. Gastric cancer findings also differ: a 2022 review combining randomized and nonrandomized studies reported early survival benefits, while another 2022 review restricted to randomized trials found no significant benefit at one, two or three years, but a benefit at five years.
For ovarian cancer, a 2022 review included six randomized trials with 737 patients. In the subgroup of 393 patients with newly diagnosed advanced disease who received chemotherapy before surgery, adding HIPEC improved survival at five years. The recurrent-cancer subgroup, involving 218 patients, showed no significant five-year survival advantage. Older 2019 reviews had reported longer overall survival in recurrent ovarian cancer, whereas randomized-trial reviews in 2022 and 2025 did not establish that benefit.
For endometrial cancer that had spread to the abdominal lining, a 2024 review compared 21 studies of surgery alone, covering 1,116 patients, with 10 studies of surgery plus HIPEC, covering 152 patients. Pooled survival at one year was 82.28% with HIPEC versus 64.68% without it; at two years it was 56.07% versus 36.95%. At five years, the difference of 21.88% versus 16.45% was not statistically significant. These were comparisons across separate collections of studies, not a single randomized head-to-head trial; differences were also less statistically convincing when the analysis was restricted to studies published after 2010. These figures describe that specific cancer population, not the expected outcome for every person having HIPEC.
Potential problems discussed in ovarian cancer research include kidney toxicity, injury to the stomach or intestines, and delayed recovery. Evidence about severe complications has changed: a 2022 review of randomized ovarian cancer trials found no statistically significant difference in severe adverse events between treatment groups, whereas a 2025 review of eight randomized trials involving 1,259 patients found more severe adverse events with HIPEC. The survival findings therefore need to be considered alongside the additional treatment burden, rather than treating HIPEC as a risk-free addition to surgery.
HIPEC can add to the time spent in hospital. In a 2025 review of eight randomized ovarian cancer trials involving 1,259 patients, surgery with HIPEC increased the initial hospital stay by an average of 1.49 days compared with surgery without HIPEC; this is an additional stay, not the total recovery time.
Nutrition is part of preparation and recovery. A 2023 review of 25 studies of surgery with HIPEC found that poor nutritional status before treatment was associated with postoperative infections and longer hospital stays in several studies. Nutritional assessment can include a clinical assessment of nourishment and measurements of muscle loss, rather than relying on body weight alone.
| Specialist | Clinic | Operations and experience | Ask about treatment |
|---|---|---|---|
Joseph Klauzner | Sourasky Medical Center (Ichilov) Tel Aviv, Israel | Removal of liver cancer; Removal of colon cancer; Prostatectomy; Stomach cancer surgery; Da Vinci Robotic System; Small intestine resection; Hyperthermic Intraperitoneal Chemotherapy (HIPEC); Whipple surgery; Colectomy (large bowel resection); Liver resection; Rectal resection; Gastroectomy; Pancreatic cancer surgery In practice since 1984 | Ask about treatment |
Ron Greenberg | Sourasky Medical Center (Ichilov) Tel Aviv, Israel | Removal of liver cancer; Removal of colon cancer; Stomach cancer surgery; Esophagectomy; Small intestine resection; Hyperthermic Intraperitoneal Chemotherapy (HIPEC); Whipple surgery; Colectomy (large bowel resection); Liver resection; Rectal resection; Gastroectomy In practice since 1991 | Ask about treatment |
Almog Ben Yaacov | Sheba Medical Center Ramat Gan, Israel | Removal of liver cancer; Removal of colon cancer; Stomach cancer surgery; Da Vinci Robotic System; Esophagectomy; Small intestine resection; Hyperthermic Intraperitoneal Chemotherapy (HIPEC); Whipple surgery; Magnetic Resonance-guided Focused Ultrasound Surgery (MRgFUS); Colectomy (large bowel resection); Liver resection; Gastroectomy; Pancreatic cancer surgery In practice since 2006 | Ask about treatment |
Ido Wolf | Sourasky Medical Center (Ichilov) Tel Aviv, Israel | Hyperthermic Intraperitoneal Chemotherapy (HIPEC); Pancreatic cancer surgery In practice since 1992 | Ask about treatment |
| Specialist | Clinic | Operations and experience | Ask about treatment |
|---|---|---|---|
Mustafa Solak | Hisar Hospital Intercontinental Istanbul, Turkey | Mastectomy; Thyroid resection; Removal of liver cancer; Removal of colon cancer; Prostatectomy; Removal of spinal cord tumor; Melanoma surgery; Nephrectomy; Stomach cancer surgery; Da Vinci Robotic System; Esophagectomy; Small intestine resection; Robotic da Vinci prostatectomy; Transurethral resection of the prostate (TURP); Breast cancer surgery; Hysterectomy (uterus removal); Lumpectomy; Hyperthermic Intraperitoneal Chemotherapy (HIPEC); Whipple surgery; Orchiectomy; Mohs microsurgery; Hysterectomy with DaVinci robot; Lung cancer surgery; Bladder removal; Colectomy (large bowel resection); Liver resection; Removal of meningioma; Rectal resection; Removal of testicle tumor; Throat cancer operation; Tongue cancer surgery; Gastroectomy; Pancreatic cancer surgery; Bladder removal with reconstruction; Laparoscopic Hysterectomy In practice since 2006 | Ask about treatment |
Ayhan Erdemir | Anadolu Medical Center Istanbul, Turkey | Stomach cancer surgery; Breast cancer surgery; Hyperthermic Intraperitoneal Chemotherapy (HIPEC); Whipple surgery In practice since 2003 | Ask about treatment |
Mustafa Ozdogan | Memorial Göztepe Hospital Istanbul, Turkey | Mastectomy; Breast cancer surgery; Hyperthermic Intraperitoneal Chemotherapy (HIPEC); Lung cancer surgery In practice since 2012 | Ask about treatment |
Cem Yalcinkaya | Anadolu Medical Center Istanbul, Turkey | Da Vinci Robotic System; Hysterectomy (uterus removal); Hyperthermic Intraperitoneal Chemotherapy (HIPEC); Hysterectomy with DaVinci robot; Laparoscopic Hysterectomy In practice since 2006 | Ask about treatment |
Abdulcabbar Kartal | Anadolu Medical Center Istanbul, Turkey | Removal of colon cancer; Stomach cancer surgery; Esophagectomy; Hyperthermic Intraperitoneal Chemotherapy (HIPEC); Whipple surgery; Colectomy (large bowel resection); Liver resection; Rectal resection; Pancreatic cancer surgery In practice since 2007 | Ask about treatment |
Kivanc Derya Peker | Hisar Hospital Intercontinental Istanbul, Turkey | Thyroid resection; Removal of liver cancer; Removal of colon cancer; Stomach cancer surgery; Hyperthermic Intraperitoneal Chemotherapy (HIPEC); Whipple surgery; Colectomy (large bowel resection); Liver resection; Rectal resection; Pancreatic cancer surgery In practice since 2004 | Ask about treatment |
Mursit Dincer | Memorial Göztepe Hospital Istanbul, Turkey | Hyperthermic Intraperitoneal Chemotherapy (HIPEC) In practice since 2015 | Ask about treatment |
| Specialist | Clinic | Operations and experience | Ask about treatment |
|---|---|---|---|
Viola Fox | Medical Center in Solingen Solingen, Germany | Mastectomy; Thyroid resection; Removal of liver cancer; Removal of colon cancer; Prostatectomy; Melanoma surgery; Stomach cancer surgery; Da Vinci Robotic System; Esophagectomy; Small intestine resection; Robotic da Vinci prostatectomy; Breast cancer surgery; Hysterectomy (uterus removal); Hyperthermic Intraperitoneal Chemotherapy (HIPEC); Whipple surgery; Hysterectomy with DaVinci robot; Lung cancer surgery; Colectomy (large bowel resection); Liver resection; Removal of meningioma; Rectal resection; Removal of testicle tumor; Throat cancer operation; Tongue cancer surgery; Gastroectomy; Pancreatic cancer surgery; Bladder removal with reconstruction; Laparoscopic Hysterectomy In practice since 2012 | Ask about treatment |
Wolfgang Schröder | Helios Gesundheit Wuppertal, Germany | Removal of liver cancer; Removal of colon cancer; Nephrectomy; Stomach cancer surgery; Da Vinci Robotic System; Esophagectomy; Small intestine resection; Breast cancer surgery; Lumpectomy; Hyperthermic Intraperitoneal Chemotherapy (HIPEC); Whipple surgery; Mohs microsurgery; Lung cancer surgery; Colectomy (large bowel resection); Liver resection; Rectal resection; Throat cancer operation; Gastroectomy; Pancreatic cancer surgery In practice since 2001 | Ask about treatment |
Lars Bönicke | Helios Gesundheit Wuppertal, Germany | Removal of liver cancer; Removal of colon cancer; Stomach cancer surgery; Da Vinci Robotic System; Esophagectomy; Small intestine resection; Hyperthermic Intraperitoneal Chemotherapy (HIPEC); Whipple surgery; Orchiectomy; Colectomy (large bowel resection); Liver resection; Rectal resection In practice since 2011 | Ask about treatment |
| Specialist | Clinic | Operations and experience | Ask about treatment |
|---|---|---|---|
Thomas Bachleitner-Hofmann | Confraternitaet & Goldenes Kreuz Private Clinic Vienna, Austria | Removal of colon cancer; Small intestine resection; Breast cancer surgery; Hyperthermic Intraperitoneal Chemotherapy (HIPEC); Colectomy (large bowel resection); Rectal resection In practice since 2001 | Ask about treatment |
| Specialist | Clinic | Operations and experience | Ask about treatment |
|---|---|---|---|
Domenico Sabia | Centro Médico Teknon Barcelona, Spain | Removal of colon cancer; Small intestine resection; Hyperthermic Intraperitoneal Chemotherapy (HIPEC); Colectomy (large bowel resection); Rectal resection In practice since 2002 | Ask about treatment |
Carlos Garcia Vasquez | Digestive Surgery and Gastroenterology Specialist Centro PAD Madrid, Spain | Removal of liver cancer; Removal of colon cancer; Stomach cancer surgery; Da Vinci Robotic System; Small intestine resection; Hyperthermic Intraperitoneal Chemotherapy (HIPEC); Colectomy (large bowel resection); Liver resection; Rectal resection; Gastroectomy In practice since 2006 | Ask about treatment |
| Specialist | Clinic | Operations and experience | Ask about treatment |
|---|---|---|---|
Luan Tianyan | Boao International Medical Center Qionghai, China | Hyperthermic Intraperitoneal Chemotherapy (HIPEC) In practice since 2006 | Ask about treatment |
| Public programme | Clinic | Recorded price | Programme details | Request a quote |
|---|---|---|---|---|
| Teknon Onology Institute: Pancreatic cancer treatment with PIPAC or HIPEC | Centro Médico Teknon | USD 21306.18Bookimed offer, Oct 2026 |
What the programme includesTeknon Onology Institute: Pancreatic cancer treatment with PIPAC or HIPEC Included: Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Excluded: Airfare Excluded: Additional activities not included Source differences
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| Public programme | Clinic | Recorded price | Programme details | Request a quote |
|---|---|---|---|---|
| HIPEC for Peritoneal Cancer by Medical Oncology Specialist — 7-Day Program | Liv Bona Dea Hospital Baku | USD 7400Bookimed offer, Oct 2026 |
What the programme includesHIPEC for Peritoneal Cancer by Medical Oncology Specialist — 7-Day Program Included: Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Included: Consultation with a doctor Included: Preoperative tests Included: Transfer airport-hotel-clinic-airport Excluded: Airfare Excluded: Hotel Excluded: Additional activities not included Excluded: Accommodation is not included Stay: 4 days in the hospital Stay: 7 days in the hotel Source differences
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| Public programme | Clinic | Recorded price | Programme details | Request a quote |
|---|---|---|---|---|
| Multidisciplinary Cancer Treatment Evaluation – Valerii Andriichuk | Anadolu Medical Center | USD 1510Bookimed offer, Oct 2026 |
What the programme includesMultidisciplinary Cancer Treatment Evaluation – Valerii Andriichuk Included: PET/CT Included: Complete blood count Included: Consultation with an oncologist Included: Abdominal MRI Included: Consultation of a radiologist Included: Consultation with creation of treatment plan Included: Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Included: Transfer airport-clinic-airport Excluded: Airfare Excluded: Hotel Excluded: Additional activities not included Excluded: Accommodation is not included |
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| Public programme | Clinic | Recorded price | Programme details | Request a quote |
|---|---|---|---|---|
| HIPEC Oncothermia Hyperthermia Therapy by German-Trained Oncologist | Biological Medicine – Integrative Health Center Baku | USD 1300Bookimed offer, Oct 2026 |
What the programme includesHIPEC Oncothermia Hyperthermia Therapy by German-Trained Oncologist Included: Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Included: Oncothermia Included: Consultation with an oncologist Included: Apartments Included: Transfer airport-hotel-airport Excluded: Airfare Excluded: Additional activities not included Stay: 15 days in the hotel Source differences
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| Public programme | Clinic | Recorded price | Programme details | Request a quote |
|---|---|---|---|---|
| HIPEC for Stomach/ Colon/ Ovarian/Appendix Cancer at Sheba Hospital- Top-10 Hospitals 2026 by Newsweek | Sheba Medical Center | USD 71400Bookimed offer, Oct 2026 |
What the programme includesHIPEC for Stomach/ Colon/ Ovarian/Appendix Cancer at Sheba Hospital- Top-10 Hospitals 2026 by Newsweek Included: Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Included: Medical Examination for pre-operation Included: General anesthesia Included: Preoperative tests Included: Blood tests Included: Echocardiography Included: Complete blood count (CBC) Included: Biochemistry blood test Included: MRI of one area Included: PET/CT Included: Consultation with an oncologist Included: Consultation with a surgeon Included: Histopathology revision Included: Complete blood count with cancer markers and a proteinogram Included: Hospitalization + afterward hotel stay Excluded: Airfare Excluded: Additional activities not included Excluded: Transfer is not included Stay: 8 days in the hospital Stay: 14 days in the hotel Source differences
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| Advanced HIPEC Surgery at Sheba Hospital- JCI accreditated and Top-10 Hospitals 2025 by Newsweek | Sheba Medical Center | USD 65000Bookimed offer, Oct 2026 |
What the programme includesAdvanced HIPEC Surgery at Sheba Hospital- JCI accreditated and Top-10 Hospitals 2025 by Newsweek Included: Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Included: Medical Examination for pre-operation Included: General anesthesia Included: Preoperative tests Included: Blood tests Included: Echocardiography Included: Complete blood count (CBC) Included: Biochemistry blood test Included: MRI of one area Included: PET/CT Included: Consultation with an oncologist Included: Consultation with a surgeon Included: Histopathology revision Included: Complete blood count with cancer markers and a proteinogram Included: Hospitalization + afterward hotel stay Excluded: Airfare Excluded: Additional activities not included Excluded: Transfer is not included Stay: 8 days in the hospital Stay: 14 days in the hotel Source differences
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| Public programme | Clinic | Recorded price | Programme details | Request a quote |
|---|---|---|---|---|
| CAR-T Therapy from Professor Liu Tianshu’s Team in Zhongshan Hospital Fudan | Shanghai Tongji Hospital, International Department | USD 280000Bookimed offer, Oct 2026 |
What the programme includesCAR-T Therapy from Professor Liu Tianshu’s Team in Zhongshan Hospital Fudan Included: CT (computer tomography) Included: Whole-body MRI Included: Brain MRI Included: Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Included: CAR-T for DLBCL Excluded: Airfare Excluded: Additional activities not included Excluded: Accommodation is not included Excluded: Transfer is not included |
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| CAR-T Therapy from Professor Liu Tianshu’s Team in Zhongshan Hospital Fudan | Shanghai Tongji Hospital, International Department | USD 280000Bookimed offer, Oct 2026 |
What the programme includesCAR-T Therapy from Professor Liu Tianshu’s Team in Zhongshan Hospital Fudan Included: CT (computer tomography) Included: Whole-body MRI Included: Brain MRI Included: Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Included: CAR-T for DLBCL Excluded: Airfare Excluded: Additional activities not included Excluded: Accommodation is not included Excluded: Transfer is not included |
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| Public programme | Clinic | Recorded price | Programme details | Request a quote |
|---|---|---|---|---|
| Cytoreductive Surgery + HIPEC | Memorial Göztepe Hospital | USD 30120Bookimed offer, Oct 2026 |
What the programme includesCytoreductive Surgery + HIPEC Included: Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Included: Transfer airport-hotel-clinic-airport Excluded: Airfare Excluded: Hotel Excluded: Additional activities not included Excluded: Accommodation is not included Stay: 7 days in the hospital |
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| Cytoreductive Surgery + HIPEC (Complex) | Memorial Göztepe Hospital | USD 34500Bookimed offer, Oct 2026 |
What the programme includesCytoreductive Surgery + HIPEC (Complex) Included: Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Included: Transfer airport-hotel-clinic-airport Excluded: Airfare Excluded: Hotel Excluded: Additional activities not included Excluded: Accommodation is not included Stay: 5 days in the hospital |
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| Public programme | Clinic | Recorded price | Programme details | Request a quote |
|---|---|---|---|---|
| Cytoreductive Surgery + HIPEC | Memorial Şişli Hospital | USD 30120Bookimed offer, Oct 2026 |
What the programme includesCytoreductive Surgery + HIPEC Included: Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Included: Transfer airport-hotel-clinic-airport Excluded: Airfare Excluded: Hotel Excluded: Additional activities not included Excluded: Accommodation is not included Stay: 7 days in the hospital |
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| Cytoreductive Surgery + HIPEC (Complex) | Memorial Şişli Hospital | USD 34500Bookimed offer, Oct 2026 |
What the programme includesCytoreductive Surgery + HIPEC (Complex) Included: Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Included: Transfer airport-hotel-clinic-airport Excluded: Airfare Excluded: Hotel Excluded: Additional activities not included Excluded: Accommodation is not included Stay: 5 days in the hospital |
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| Public programme | Clinic | Recorded price | Programme details | Request a quote |
|---|---|---|---|---|
| Cytoreductive Surgery + HIPEC | Memorial Bahçelievler Hospital | USD 30120Bookimed offer, Oct 2026 |
What the programme includesCytoreductive Surgery + HIPEC Included: Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Included: Transfer airport-hotel-clinic-airport Excluded: Airfare Excluded: Hotel Excluded: Additional activities not included Excluded: Accommodation is not included Stay: 7 days in the hospital |
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| Cytoreductive Surgery + HIPEC (Complex) | Memorial Bahçelievler Hospital | USD 34500Bookimed offer, Oct 2026 |
What the programme includesCytoreductive Surgery + HIPEC (Complex) Included: Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Included: Transfer airport-hotel-clinic-airport Excluded: Airfare Excluded: Hotel Excluded: Additional activities not included Excluded: Accommodation is not included Stay: 5 days in the hospital |
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| Public programme | Clinic | Recorded price | Programme details | Request a quote |
|---|---|---|---|---|
| Cytoreductive Surgery + HIPEC | Memorial Ataşehir Hospital | USD 30120Bookimed offer, Oct 2026 |
What the programme includesCytoreductive Surgery + HIPEC Included: Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Included: Transfer airport-hotel-clinic-airport Excluded: Airfare Excluded: Hotel Excluded: Additional activities not included Excluded: Accommodation is not included Stay: 7 days in the hospital |
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| Cytoreductive Surgery + HIPEC (Complex) | Memorial Ataşehir Hospital | USD 34500Bookimed offer, Oct 2026 |
What the programme includesCytoreductive Surgery + HIPEC (Complex) Included: Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Included: Transfer airport-hotel-clinic-airport Excluded: Airfare Excluded: Hotel Excluded: Additional activities not included Excluded: Accommodation is not included Stay: 5 days in the hospital |
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| Public programme | Clinic | Recorded price | Programme details | Request a quote |
|---|---|---|---|---|
| Treatment for Colorectal, Peritoneal and Gynecological Cancers | Digestive Surgery and Gastroenterology Specialist Centro PAD | USD 21890Bookimed offer, Oct 2026 |
What the programme includesTreatment for Colorectal, Peritoneal and Gynecological Cancers Included: Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Included: 24-hr nurse services Included: Consultation with an anesthesiologist Included: Consultation with a surgeon Included: Hospitalization Included: Transfer to the clinic Excluded: Airfare Excluded: Hotel Excluded: Additional activities not included Stay: 10 days in the hospital Additional source terms: Your surgeon is always Dr. Carlos Garcia Vasquez: he personally performs every surgery, and the surgeon who assesses you is the surgeon who operates on you. Cytoreductive surgery (CRS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for peritoneal carcinomatosis from colorectal, gastric, appendiceal, ovarian or primary peritoneal cancers, performed by Dr. Carlos Garcia Vasquez, surgical oncologist and colorectal surgeon, at HLA Moncloa University Hospital, Madrid (recognized among the World’s Best Smart Hospitals 2023 by Newsweek). The package includes evaluation of surgical candidacy (review of staging and estimation of the Peritoneal Cancer Index), anesthesia assessment, the CRS + HIPEC procedure, 10 nights in hospital including intensive or intermediate care as needed, and post-operative surgical follow-up. Hotel–clinic transfer included. Hotel accommodation is not included. Systemic chemotherapy and long-term oncological follow-up are not included. Each case is reviewed individually; an online consultation is available before travelling. Additional charges: Your surgeon is always Dr. Carlos Garcia Vasquez: he personally performs every surgery, and the surgeon who assesses you is the surgeon who operates on you. Cytoreductive surgery (CRS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for peritoneal carcinomatosis from colorectal, gastric, appendiceal, ovarian or primary peritoneal cancers, performed by Dr. Carlos Garcia Vasquez, surgical oncologist and colorectal surgeon, at HLA Moncloa University Hospital, Madrid (recognized among the World’s Best Smart Hospitals 2023 by Newsweek). The package includes evaluation of surgical candidacy (review of staging and estimation of the Peritoneal Cancer Index), anesthesia assessment, the CRS + HIPEC procedure, 10 nights in hospital including intensive or intermediate care as needed, and post-operative surgical follow-up. Hotel–clinic transfer included. Hotel accommodation is not included. Systemic chemotherapy and long-term oncological follow-up are not included. Each case is reviewed individually; an online consultation is available before travelling. Source differences
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