{"schema_version":"bookimed.page-context.v1","id":"hcm-myectomy","url":"https://hub.bookimed.com/heart-surgery/hcm-myectomy/","json_url":"https://hub.bookimed.com/wp-content/uploads/heart-surgery-hub-20261007/pages/hcm-myectomy.json","index_url":"https://hub.bookimed.com/wp-content/uploads/heart-surgery-hub-20261007/pages/index.json","full_dataset_url":"https://hub.bookimed.com/wp-content/uploads/heart-surgery-hub-20261007/content.json","content_revision":"source-driven-rankings-20261008","date_modified":"2026-10-08","language":"en","kind":"guide","title":"Septal myectomy for obstructive HCM: compare treatment options","summary":"Septal myectomy removes selected thickened heart muscle to relieve obstruction in symptomatic HCM. The operation can also address contributing mitral or supporting structures. HCM care and rhythm-risk assessment continue after obstruction is treated.","research_credit":{"name":"Yevhenii Kozlov","role":"Co-Founder of Bookimed","url":"https://us-uk.bookimed.com/ceo/kozlov/","contribution":"Research personally prepared and reviewed","assistance":"AI tools assisted source research."},"editorial_scope":"Source-based patient information; an individual treatment plan requires clinical review.","research_method":"How this guide is researched and compared Research project led by Yevhenii Kozlov . We link clinical guidance, primary studies and named hospital or offer sources beside the relevant statements. Comparisons distinguish individual operators from programme results and preserve the study population, follow-up and limitations. Prices are dated examples with their stated scope. Research and editorial preparation are separate from clinical review; no named clinician has medically reviewed this edition. Bookimed provides care coordination. Partner and reference programmes are identified from their sources; paid ordering is not used in our published-cohort comparison. Read the editorial policy .","key_takeaways":[{"label":"50 mmHg is a decision threshold","text":"A resting or provoked LVOT gradient of at least 50 mmHg supports advanced-treatment assessment when symptoms persist; the number alone is not an indication for surgery.","sources":["D07"]},{"label":"100 patients in the MESM study","text":"The Zhejiang series reported mean outflow gradient falling from 85.8 to 8.4 mmHg through a 4–5 cm underarm incision.","sources":["rank-cui100"]},{"label":"$25,000–40,000 Cui programme budget","text":"Estimated programme cost of $25,000–40,000 USD. Cleveland and NYU provide individual quotations.","sources":[]}],"benefits":[{"text":"Myectomy can directly remove the obstructing muscle and allow associated mitral or subvalvular correction in the same operation.","sources":["C10"]},{"text":"Preserving the breastbone removes a major recovery burden: healing a surgically divided sternum. Daily movement can focus on comfort, the chest-wall wound and gradually rebuilding activity.","sources":["tp-cui100","br-sternum-gstt"]}],"limitations":[{"text":"Myectomy carries surgical and conduction risks, including a possible pacemaker. It treats obstruction rather than every aspect of HCM; small-incision cohorts do not prove faster full recovery than matched conventional surgery.","sources":["DX10","rank-cui100"]}],"sections":[{"id":"benefit-balance","title":"Benefits and trade-offs","text":"Benefits and trade-offs Potential advantages Myectomy can directly remove the obstructing muscle and allow associated mitral or subvalvular correction in the same operation. Sources: AHA/ACC HCM guidance (2024) Preserving the breastbone removes a major recovery burden: healing a surgically divided sternum. Daily movement can focus on comfort, the chest-wall wound and gradually rebuilding activity. Sources: MESM: 100-patient observational study · Guy’s and St Thomas’: breastbone healing and movement after heart surgery Trade-offs and limits Myectomy carries surgical and conduction risks, including a possible pacemaker. It treats obstruction rather than every aspect of HCM; small-incision cohorts do not prove faster full recovery than matched conventional surgery. Sources: Septal myectomy: procedure and risks · Minimally Invasive Electro Septal Myectomy for HOCM Through a Right Infra-Axillary Incision","links":[{"label":"AHA/ACC HCM guidance (2024)","url":"https://www.acc.org/Latest-in-Cardiology/ten-points-to-remember/2024/05/06/15/12/2024-hypertrophic-cardiomyopathy-gl"},{"label":"MESM: 100-patient observational study","url":"https://pubmed.ncbi.nlm.nih.gov/41109584/"},{"label":"Guy’s and St Thomas’: breastbone healing and movement after heart surgery","url":"https://www.guysandstthomas.nhs.uk/health-information/physiotherapy-heart-surgery"},{"label":"Septal myectomy: procedure and risks","url":"https://my.clevelandclinic.org/health/treatments/17461-septal-myectomy"},{"label":"Minimally Invasive Electro Septal Myectomy for HOCM Through a Right Infra-Axillary Incision","url":"https://doi.org/10.1016/j.athoracsur.2025.09.023"}]},{"id":"treatment-programmes","title":"Compare complete treatment programmes","text":"Compare complete treatment programmes Hangzhou, China Yong Cui · HCM surgery ↗ Yong Cui Zhejiang Provincial People’s Hospital A 4–5 cm underarm incision keeps the breastbone intact: no divided breastbone to heal while you rebuild walking and everyday activity. $25,000–40,000 estimated cost USD · estimated programme range · updated 8 October 2026. Published 100-patient MESM series; separate 132-patient mid-cavity conference report and earlier 148-patient modified-Morrow study. See method, care and package ↗ Cleveland, United States Nicholas Smedira · complex HCM surgery ↗ Nicholas Smedira Cleveland Clinic HCM Center Specialist HCM imaging and myectomy that can also correct mitral-leaflet or papillary-muscle causes of obstruction. Quote on request Individual estimate after assessment. A historical series of 1,559 LVOT operations, including 1,530 myectomies and 522 myectomies with mitral or subvalvular intervention. See method, care and package ↗ New York, United States NYU HCM team · anatomy and access choices ↗ Daniel Swistel · Joshua Scheinerman NYU Langone Hypertrophic Cardiomyopathy Program An HCM team that treats septal and mitral causes of obstruction, with conventional and selected robotic surgical approaches. Quote on request Individual estimate after assessment. NYU reports more than 600 myectomies at programme level. Supporting method evidence includes a historical 77-patient anatomy study and a separate first robotic case report. See method, care and package ↗ Treatment programmes ↗","links":[{"label":"Yong Cui · HCM surgery ↗","url":"https://hub.bookimed.com/heart-surgery/programme-cui-hcm/"},{"label":"See method, care and package ↗","url":"https://hub.bookimed.com/heart-surgery/programme-cui-hcm/"},{"label":"Nicholas Smedira · complex HCM surgery ↗","url":"https://hub.bookimed.com/heart-surgery/programme-cleveland-hcm/"},{"label":"See method, care and package ↗","url":"https://hub.bookimed.com/heart-surgery/programme-cleveland-hcm/"},{"label":"NYU HCM team · anatomy and access choices ↗","url":"https://hub.bookimed.com/heart-surgery/programme-nyu-hcm/"},{"label":"See method, care and package ↗","url":"https://hub.bookimed.com/heart-surgery/programme-nyu-hcm/"},{"label":"Treatment programmes ↗","url":"https://hub.bookimed.com/heart-surgery/treatment-programmes/"}]},{"id":"breastbone-benefit","title":"What keeping your breastbone intact changes","text":"What keeping your breastbone intact changes The practical advantage is more than a smaller scar: the sternum is not divided. After a sternotomy, everyday movements such as pushing out of a chair, lifting a shopping bag or getting out of bed have to take the healing breastbone into account. Guy’s and St Thomas’ describes about three months for full breastbone healing after sternotomy and gives different movement guidance for approaches between the ribs. Preserving the sternum removes that bone-healing step; the incision and the heart still recover gradually. Recovery detail Sternotomy Cui’s planned underarm MESM access Breastbone Divided and secured after surgery; bone healing continues over the following months. Left intact; no sternotomy bone wound to heal. Everyday upper-body movement Movement and lifting guidance protects the healing sternum. No divided sternum to protect; activity progresses with wound comfort and the clinical recovery plan. Incision and scar An incision along the front of the chest. A 4–5 cm incision beneath the right arm in the published MESM series. Sources: MESM: 100-patient observational study · Guy’s and St Thomas’: breastbone healing and movement after heart surgery · Mayo Clinic: minimally invasive surgery","links":[{"label":"MESM: 100-patient observational study","url":"https://pubmed.ncbi.nlm.nih.gov/41109584/"},{"label":"Guy’s and St Thomas’: breastbone healing and movement after heart surgery","url":"https://www.guysandstthomas.nhs.uk/health-information/physiotherapy-heart-surgery"},{"label":"Mayo Clinic: minimally invasive surgery","url":"https://www.mayoclinic.org/tests-procedures/minimally-invasive-heart-surgery/about/pac-20384895"}],"tables":[[["Recovery detail","Sternotomy","Cui’s planned underarm MESM access"],["Breastbone","Divided and secured after surgery; bone healing continues over the following months.","Left intact; no sternotomy bone wound to heal."],["Everyday upper-body movement","Movement and lifting guidance protects the healing sternum.","No divided sternum to protect; activity progresses with wound comfort and the clinical recovery plan."],["Incision and scar","An incision along the front of the chest.","A 4–5 cm incision beneath the right arm in the published MESM series."]]]},{"id":"latent-obstruction","title":"Obstruction only during exercise? Find your pathway","text":"Obstruction only during exercise? Find your pathway A resting scan can miss the degree of dynamic obstruction that appears with exertion. If your report mentions latent obstruction, exercise-induced LVOTO, SAM or papillary-muscle abnormalities, use the dedicated guide to understand what a specialist review should address. Sources: 2024 HCM guideline: official teaching slides Latent obstruction & SAM ↗ Compare surgeon expertise ↗","links":[{"label":"2024 HCM guideline: official teaching slides","url":"https://professional.heart.org/-/media/PHD-Files/Education/2024_HCM_Guideline_for_the_Management_of_HCM_Slide_Deck.pdf"},{"label":"Latent obstruction & SAM ↗","url":"https://hub.bookimed.com/heart-surgery/latent-obstructive-hcm/"},{"label":"Compare surgeon expertise ↗","url":"https://hub.bookimed.com/heart-surgery/septal-myectomy-surgeon-comparison/"}]},{"id":"assessment","title":"When does septal reduction enter the discussion?","text":"When does septal reduction enter the discussion? This comparison concerns adults with obstructive HCM. The specialist must link limiting symptoms to obstruction despite appropriate treatment. A resting or provoked LVOT gradient of at least 50 mmHg generally supports consideration of advanced treatment; the number alone does not establish a need for surgery. The 2024 guidance advises against septal reduction in asymptomatic people with normal exercise capacity. Some patients with less severe symptoms merit earlier expert consideration because of other findings. Nonobstructive and apical HCM have a separate pathway. Sources: 2024 HCM guideline: official teaching slides Nonobstructive & apical HCM ↗ Latent obstruction & SAM ↗","links":[{"label":"2024 HCM guideline: official teaching slides","url":"https://professional.heart.org/-/media/PHD-Files/Education/2024_HCM_Guideline_for_the_Management_of_HCM_Slide_Deck.pdf"},{"label":"Nonobstructive & apical HCM ↗","url":"https://hub.bookimed.com/heart-surgery/nonobstructive-apical-hcm/"},{"label":"Latent obstruction & SAM ↗","url":"https://hub.bookimed.com/heart-surgery/latent-obstructive-hcm/"}]},{"id":"anatomy-and-specialists","title":"How different HCM operations address anatomy","text":"How different HCM operations address anatomy These methods solve different anatomical problems. The value of the comparison is the correction achieved, the access required and the maturity of follow-up. Anatomical finding Published approach Profiles to explore Mitral chordae contribute to obstruction Myectomy with selected secondary chordal cutting Paolo Ferrazzi / Monza An elongated leaflet or abnormal papillary position Resect–plicate–release: selected leaflet plication and papillary release Daniel Swistel / current NYU practice; historical RPR cohort A smaller chest access is under consideration Infra-axillary myectomy and a separate newer MESM series Yong Cui / Zhejiang A beating-heart transapical technique is proposed Transapical beating-heart septal myectomy Xiang Wei / Tongji Midventricular or apical disease with an aneurysm Selected transapical myectomy with aneurysm repair Mayo programme / Joseph Dearani coauthorship Conventional myectomy and associated valve disease Extended septal myectomy with anatomy-specific valve assessment Nicholas Smedira / Cleveland Sources: Ferrazzi et al. · JACC 2026 · 350 patients · Resect–plicate–release · 77-patient study (2015) · An innovative minimally invasive approach for HOCM: transaortic septal myectomy via right infra-axillary incision · Minimally Invasive Electro Septal Myectomy for HOCM Through a Right Infra-Axillary Incision · TA-BSM for obstructive HCM: Lessons Learned After the Learning Curve Period · Mayo · 67 patients with apical aneurysm repair · Surgical management of LVOT obstruction in a specialized HOCM center Paolo Ferrazzi ↗ Daniel G. Swistel ↗ Yong Cui ↗ Xiang Wei ↗ Joseph A. Dearani ↗ Nicholas Smedira ↗","links":[{"label":"Ferrazzi et al. · JACC 2026 · 350 patients","url":"https://pubmed.ncbi.nlm.nih.gov/42307496/"},{"label":"Resect–plicate–release · 77-patient study (2015)","url":"https://pubmed.ncbi.nlm.nih.gov/26272699/"},{"label":"An innovative minimally invasive approach for HOCM: transaortic septal myectomy via right infra-axillary incision","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11632347/"},{"label":"Minimally Invasive Electro Septal Myectomy for HOCM Through a Right Infra-Axillary Incision","url":"https://doi.org/10.1016/j.athoracsur.2025.09.023"},{"label":"TA-BSM for obstructive HCM: Lessons Learned After the Learning Curve Period","url":"https://doi.org/10.1161/CIRCINTERVENTIONS.124.015044"},{"label":"Mayo · 67 patients with apical aneurysm repair","url":"https://pubmed.ncbi.nlm.nih.gov/37029070/"},{"label":"Surgical management of LVOT obstruction in a specialized HOCM center","url":"https://doi.org/10.1016/j.jtcvs.2018.11.148"},{"label":"Paolo Ferrazzi ↗","url":"https://hub.bookimed.com/heart-surgery/doctor-paolo-ferrazzi/"},{"label":"Daniel G. Swistel ↗","url":"https://hub.bookimed.com/heart-surgery/doctor-daniel-swistel/"},{"label":"Yong Cui ↗","url":"https://hub.bookimed.com/heart-surgery/doctor-yong-cui/"},{"label":"Xiang Wei ↗","url":"https://hub.bookimed.com/heart-surgery/doctor-xiang-wei/"},{"label":"Joseph A. Dearani ↗","url":"https://hub.bookimed.com/heart-surgery/doctor-joseph-dearani/"},{"label":"Nicholas Smedira ↗","url":"https://hub.bookimed.com/heart-surgery/doctor-nicholas-smedira/"}],"tables":[[["Anatomical finding","Published approach","Profiles to explore"],["Mitral chordae contribute to obstruction","Myectomy with selected secondary chordal cutting","Paolo Ferrazzi / Monza"],["An elongated leaflet or abnormal papillary position","Resect–plicate–release: selected leaflet plication and papillary release","Daniel Swistel / current NYU practice; historical RPR cohort"],["A smaller chest access is under consideration","Infra-axillary myectomy and a separate newer MESM series","Yong Cui / Zhejiang"],["A beating-heart transapical technique is proposed","Transapical beating-heart septal myectomy","Xiang Wei / Tongji"],["Midventricular or apical disease with an aneurysm","Selected transapical myectomy with aneurysm repair","Mayo programme / Joseph Dearani coauthorship"],["Conventional myectomy and associated valve disease","Extended septal myectomy with anatomy-specific valve assessment","Nicholas Smedira / Cleveland"]]]},{"id":"options","title":"Medicines, myectomy or alcohol septal ablation?","text":"Medicines, myectomy or alcohol septal ablation? Initial treatment usually uses a non-vasodilating beta blocker, followed by verapamil or diltiazem if appropriate. Persistent symptoms prompt a shared discussion of further drug treatment or septal reduction at an experienced HCM centre. The options are not a mandatory sequence in which every patient must try every drug before a procedure. Option What it changes What makes the choice different Further medical treatment Can reduce symptoms and, in obstructive HCM, the gradient without removing muscle. Disopyramide or a cardiac myosin inhibitor may be considered. Response, interactions, monitoring and continued access matter. Septal myectomy A surgeon removes selected thickened septal muscle to enlarge the outflow pathway. Surgical myectomy can treat the obstructing muscle alongside mitral or papillary-muscle correction, or coronary bypass, when those problems also require surgery. Alcohol septal ablation A catheter delivers alcohol through a suitable small coronary branch to create controlled injury in the target septum. Useful when surgery is contraindicated or its risk is unacceptable. Requires suitable coronary anatomy; it cannot surgically correct associated valve or papillary-muscle abnormalities. Sources: AHA/ACC HCM guidance (2024) · Septal myectomy: procedure and risks · Alcohol septal ablation: procedure and risks · 2024 HCM guideline: official teaching slides Compare clinics ↗ Specialists ↗","links":[{"label":"AHA/ACC HCM guidance (2024)","url":"https://www.acc.org/Latest-in-Cardiology/ten-points-to-remember/2024/05/06/15/12/2024-hypertrophic-cardiomyopathy-gl"},{"label":"Septal myectomy: procedure and risks","url":"https://my.clevelandclinic.org/health/treatments/17461-septal-myectomy"},{"label":"Alcohol septal ablation: procedure and risks","url":"https://my.clevelandclinic.org/health/treatments/22498-alcohol-septal-ablation"},{"label":"2024 HCM guideline: official teaching slides","url":"https://professional.heart.org/-/media/PHD-Files/Education/2024_HCM_Guideline_for_the_Management_of_HCM_Slide_Deck.pdf"},{"label":"Compare clinics ↗","url":"https://hub.bookimed.com/heart-surgery/septal-myectomy-clinics/"},{"label":"Specialists ↗","url":"https://hub.bookimed.com/heart-surgery/septal-myectomy-surgeons/"}],"tables":[[["Option","What it changes","What makes the choice different"],["Further medical treatment","Can reduce symptoms and, in obstructive HCM, the gradient without removing muscle.","Disopyramide or a cardiac myosin inhibitor may be considered. Response, interactions, monitoring and continued access matter."],["Septal myectomy","A surgeon removes selected thickened septal muscle to enlarge the outflow pathway.","Surgical myectomy can treat the obstructing muscle alongside mitral or papillary-muscle correction, or coronary bypass, when those problems also require surgery."],["Alcohol septal ablation","A catheter delivers alcohol through a suitable small coronary branch to create controlled injury in the target septum.","Useful when surgery is contraindicated or its risk is unacceptable. Requires suitable coronary anatomy; it cannot surgically correct associated valve or papillary-muscle abnormalities."]]]},{"id":"medical-evidence","title":"Myosin inhibitors: evidence, monitoring and access","text":"Myosin inhibitors: evidence, monitoring and access Mavacamten and aficamten are examples of cardiac myosin inhibitors with US approvals for symptomatic obstructive HCM; access and approved use differ by country. The FDA’s aficamten evidence came from a placebo-controlled trial in 282 adults, with the primary exercise-capacity assessment at 24 weeks. This was not a comparison against myectomy or septal ablation. Mavacamten can reduce pumping strength excessively and cause heart failure. Treatment includes repeated echocardiography and review of interacting medicines, including after returning home; symptom relief does not remove that monitoring burden. Sources: MYQORZO (aficamten): FDA drug trials snapshot · CAMZYOS prescribing information, April 2025 revision","links":[{"label":"MYQORZO (aficamten): FDA drug trials snapshot","url":"https://www.fda.gov/drugs/drug-trials-snapshots/drug-trials-snapshots-myqorzo"},{"label":"CAMZYOS prescribing information, April 2025 revision","url":"https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/214998s010lbl.pdf"}]},{"id":"risk-comparison","title":"Compare risk and benefit on the same terms","text":"Compare risk and benefit on the same terms Myectomy and alcohol septal ablation can both cause conduction problems, including a need for permanent pacing. Surgery allows direct correction of associated structures; ablation relies on suitable coronary-branch anatomy and cannot surgically repair a valve. The published MESM series reported four permanent pacemakers among 100 patients and no observed in-hospital deaths. This describes a selected centre cohort, not a zero-risk operation or a comparative safety advantage. Sources: Septal myectomy: procedure and risks · Alcohol septal ablation: procedure and risks · Minimally Invasive Electro Septal Myectomy for HOCM Through a Right Infra-Axillary Incision Compare surgeon expertise ↗ Recovery ↗","links":[{"label":"Septal myectomy: procedure and risks","url":"https://my.clevelandclinic.org/health/treatments/17461-septal-myectomy"},{"label":"Alcohol septal ablation: procedure and risks","url":"https://my.clevelandclinic.org/health/treatments/22498-alcohol-septal-ablation"},{"label":"Minimally Invasive Electro Septal Myectomy for HOCM Through a Right Infra-Axillary Incision","url":"https://doi.org/10.1016/j.athoracsur.2025.09.023"},{"label":"Compare surgeon expertise ↗","url":"https://hub.bookimed.com/heart-surgery/septal-myectomy-surgeon-comparison/"},{"label":"Recovery ↗","url":"https://hub.bookimed.com/heart-surgery/recovery/"}]},{"id":"cui","title":"An infra-axillary approach to myectomy: Yong Cui’s published work","text":"An infra-axillary approach to myectomy: Yong Cui’s published work Yong Cui / Cui Yong (崔勇) is a cardiovascular surgeon associated with Zhejiang Provincial People’s Hospital in a 2024 JTCVS Techniques publication. The published discussion describes transaortic septal myectomy through a right infra-axillary incision. The clinical connection is specific: an alternative route to a myectomy for selected obstructive HCM cases. It does not establish that this approach is suitable for every patient or that its results surpass programmes using another route. Cui’s practice website describes his department-lead role and trans-axillary valve work. The HCM publications provide more specific evidence: they identify the operation, patient cohort, haemodynamic results and complications. Sources: An innovative minimally invasive approach for HOCM: transaortic septal myectomy via right infra-axillary incision · Yong Cui practice profile Specialists ↗","links":[{"label":"An innovative minimally invasive approach for HOCM: transaortic septal myectomy via right infra-axillary incision","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11632347/"},{"label":"Yong Cui practice profile","url":"https://dryongcuiheartsurgery.com/"},{"label":"Specialists ↗","url":"https://hub.bookimed.com/heart-surgery/septal-myectomy-surgeons/"}]},{"id":"compare","title":"What the published myectomy experience shows","text":"What the published myectomy experience shows Cui’s 100-patient MESM series describes a defined small-incision technique and short-term results. Cleveland’s historical series describes 1,559 LVOTO operations, of which 1,530 involved myectomy and 522 included associated mitral or subvalvular work. These data reveal operative scope and patient selection. They do not establish annual personal volume, and their different time periods and techniques prevent a country-wide performance ratio. Sources: Minimally Invasive Electro Septal Myectomy for HOCM Through a Right Infra-Axillary Incision · Surgical management of LVOT obstruction in a specialized HOCM center","links":[{"label":"Minimally Invasive Electro Septal Myectomy for HOCM Through a Right Infra-Axillary Incision","url":"https://doi.org/10.1016/j.athoracsur.2025.09.023"},{"label":"Surgical management of LVOT obstruction in a specialized HOCM center","url":"https://doi.org/10.1016/j.jtcvs.2018.11.148"}]},{"id":"cost","title":"Septal myectomy cost: programme budgets and individual quotes","text":"Septal myectomy cost: programme budgets and individual quotes A useful myectomy quote should specify septal muscle removal and any planned work on the mitral valve, chordae or papillary muscles. These are different operative scopes. A small-incision technique name alone does not tell you what the package includes. The Cui HCM programme in Hangzhou has an estimated cost of $25,000–40,000 USD. The final quotation reflects the myectomy plan, any additional valve work and the hospital-care scope. Cleveland and NYU provide individual estimates. Programme Price basis Included detail available Yong Cui / Zhejiang $25,000–40,000 estimated programme cost Programme budget; standard ICU, room and follow-up allowances are not itemised Cleveland HCM Individual estimate A clinical pathway is published; no standard myectomy package tariff was found NYU HCM Individual estimate Multidisciplinary HCM assessment; no standard myectomy package tariff was found Sources: AHA/ACC HCM guidance (2024) · An innovative minimally invasive approach for HOCM: transaortic septal myectomy via right infra-axillary incision · Surgical management of LVOT obstruction in a specialized HOCM center Yong Cui · HCM surgery ↗ HCM programmes ↗ Costs & quotes ↗","links":[{"label":"AHA/ACC HCM guidance (2024)","url":"https://www.acc.org/Latest-in-Cardiology/ten-points-to-remember/2024/05/06/15/12/2024-hypertrophic-cardiomyopathy-gl"},{"label":"An innovative minimally invasive approach for HOCM: transaortic septal myectomy via right infra-axillary incision","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11632347/"},{"label":"Surgical management of LVOT obstruction in a specialized HOCM center","url":"https://doi.org/10.1016/j.jtcvs.2018.11.148"},{"label":"Yong Cui · HCM surgery ↗","url":"https://hub.bookimed.com/heart-surgery/programme-cui-hcm/"},{"label":"HCM programmes ↗","url":"https://hub.bookimed.com/heart-surgery/hcm-treatment-programmes/"},{"label":"Costs & quotes ↗","url":"https://hub.bookimed.com/heart-surgery/cost/"}],"tables":[[["Programme","Price basis","Included detail available"],["Yong Cui / Zhejiang","$25,000–40,000 estimated programme cost","Programme budget; standard ICU, room and follow-up allowances are not itemised"],["Cleveland HCM","Individual estimate","A clinical pathway is published; no standard myectomy package tariff was found"],["NYU HCM","Individual estimate","Multidisciplinary HCM assessment; no standard myectomy package tariff was found"]]]},{"id":"questions","title":"What improves after myectomy, and what care continues","text":"What improves after myectomy, and what care continues Relieving obstruction can improve symptoms caused by restricted outflow. The operation does not remove the underlying need for HCM surveillance. Follow-up imaging measures the remaining outflow gradient and mitral leakage. Rhythm and sudden-death risk assessment remain separate from the success of muscle removal. Genetic counselling and family screening may still be relevant after surgery. Sources: AHA/ACC HCM guidance (2024)","links":[{"label":"AHA/ACC HCM guidance (2024)","url":"https://www.acc.org/Latest-in-Cardiology/ten-points-to-remember/2024/05/06/15/12/2024-hypertrophic-cardiomyopathy-gl"}]},{"id":"matching-specialists","title":"Specialists for this treatment pathway","text":"Specialists for this treatment pathway Explore each specialist’s clinical focus, current programme and the studies relevant to this treatment. The listed roles include cardiac surgeons and, where appropriate, interventional cardiologists. Portrait source ↗ Monza · Italy cardiac surgeon Paolo Ferrazzi → Ferrazzi’s HCM work combines septal myectomy with selective cutting of abnormal secondary mitral chordae. Monza research affiliation documented in 2026; the scientific-director appointment source is dated 2023. Policlinico di Monza → Sources: Ferrazzi et al. · JACC 2026 · 350 patients · Policlinico di Monza · heart centre brochure (2023) View expertise and research → Portrait source ↗ Hangzhou · China cardiac surgeon Yong Cui → Cui’s team has published infra-axillary transaortic myectomy and a separate newer MESM technique for obstructive HCM. Zhejiang Provincial People’s Hospital → Sources: An innovative minimally invasive approach for HOCM: transaortic septal myectomy via right infra-axillary incision · Minimally Invasive Electro Septal Myectomy for HOCM Through a Right Infra-Axillary Incision View expertise and research → Portrait source ↗ New York · United States cardiac surgeon Daniel G. Swistel → Swistel’s resect–plicate–release work addresses septal muscle, selected elongated mitral leaflets and abnormal papillary attachments. NYU Langone → Sources: Resect–plicate–release · 77-patient study (2015) · NYU Langone · Daniel Swistel · NYU Langone · HCM programme View expertise and research → JD Rochester, Minnesota · United States cardiac surgeon Joseph A. Dearani → Dearani’s Mayo practice includes septal myectomy and complex HCM anatomy. The programme also evaluates selected apical disease and associated apical aneurysms. Mayo Clinic Rochester → Sources: Mayo Clinic · Joseph Dearani · Mayo Clinic · HCM treatment options · Mayo · 67 patients with apical aneurysm repair View expertise and research → XW Wuhan · China cardiac surgeon Xiang Wei → Wei’s Tongji team developed transapical beating-heart septal myectomy. The studied technique reaches the septum through the heart’s apex without cardiopulmonary bypass. Tongji Hospital Wuhan → Sources: Tongji Hospital · cardiovascular surgery department · TA-BSM for obstructive HCM: Lessons Learned After the Learning Curve Period View expertise and research → Portrait source ↗ Cleveland, Ohio · United States cardiac surgeon Nicholas Smedira → Smedira’s Cleveland Clinic practice includes myectomy for HCM. The programme also treats selected mitral and subvalvular abnormalities that contribute to obstruction. Cleveland Clinic → Sources: Nicholas Smedira, MD — Cleveland Clinic · Surgical management of LVOT obstruction in a specialized HOCM center View expertise and research → Browse the full specialist directory →","links":[{"label":"Portrait source ↗","url":"https://www.policlinicodimonza.it/wp-content/uploads/2024/04/BROCHURE-CENTRO-CUORE-MONZA_marzo23_WEB.pdf#page=4"},{"label":"Paolo Ferrazzi →","url":"https://hub.bookimed.com/heart-surgery/doctor-paolo-ferrazzi/"},{"label":"Policlinico di Monza →","url":"https://hub.bookimed.com/heart-surgery/clinic-policlinico-monza/"},{"label":"Ferrazzi et al. · JACC 2026 · 350 patients","url":"https://pubmed.ncbi.nlm.nih.gov/42307496/"},{"label":"Policlinico di Monza · heart centre brochure (2023)","url":"https://www.policlinicodimonza.it/wp-content/uploads/2024/04/BROCHURE-CENTRO-CUORE-MONZA_marzo23_WEB.pdf"},{"label":"View expertise and research →","url":"https://hub.bookimed.com/heart-surgery/doctor-paolo-ferrazzi/"},{"label":"Portrait source ↗","url":"https://dryongcuiheartsurgery.com/"},{"label":"Yong Cui →","url":"https://hub.bookimed.com/heart-surgery/doctor-yong-cui/"},{"label":"Zhejiang Provincial People’s Hospital →","url":"https://hub.bookimed.com/heart-surgery/clinic-zhejiang/"},{"label":"An innovative minimally invasive approach for HOCM: transaortic septal myectomy via right infra-axillary incision","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11632347/"},{"label":"Minimally Invasive Electro Septal Myectomy for HOCM Through a Right Infra-Axillary Incision","url":"https://doi.org/10.1016/j.athoracsur.2025.09.023"},{"label":"View expertise and research →","url":"https://hub.bookimed.com/heart-surgery/doctor-yong-cui/"},{"label":"Portrait source ↗","url":"https://nyulangone.org/doctors/1083603690/daniel-g-swistel"},{"label":"Daniel G. Swistel →","url":"https://hub.bookimed.com/heart-surgery/doctor-daniel-swistel/"},{"label":"NYU Langone →","url":"https://hub.bookimed.com/heart-surgery/clinic-nyu-langone/"},{"label":"Resect–plicate–release · 77-patient study (2015)","url":"https://pubmed.ncbi.nlm.nih.gov/26272699/"},{"label":"NYU Langone · Daniel Swistel","url":"https://nyulangone.org/doctors/1083603690/daniel-g-swistel"},{"label":"NYU Langone · HCM programme","url":"https://nyulangone.org/care-services/hypertrophic-cardiomyopathy-program"},{"label":"View expertise and research →","url":"https://hub.bookimed.com/heart-surgery/doctor-daniel-swistel/"},{"label":"Joseph A. Dearani →","url":"https://hub.bookimed.com/heart-surgery/doctor-joseph-dearani/"},{"label":"Mayo Clinic Rochester →","url":"https://hub.bookimed.com/heart-surgery/clinic-mayo-rochester/"},{"label":"Mayo Clinic · Joseph Dearani","url":"https://www.mayoclinic.org/biographies/dearani-joseph-a-m-d/bio-20053326"},{"label":"Mayo Clinic · HCM treatment options","url":"https://www.mayoclinic.org/diseases-conditions/hypertrophic-cardiomyopathy/diagnosis-treatment/drc-20350204"},{"label":"Mayo · 67 patients with apical aneurysm repair","url":"https://pubmed.ncbi.nlm.nih.gov/37029070/"},{"label":"View expertise and research →","url":"https://hub.bookimed.com/heart-surgery/doctor-joseph-dearani/"},{"label":"Xiang Wei →","url":"https://hub.bookimed.com/heart-surgery/doctor-xiang-wei/"},{"label":"Tongji Hospital Wuhan →","url":"https://hub.bookimed.com/heart-surgery/clinic-tongji-wuhan/"},{"label":"Tongji Hospital · cardiovascular surgery department","url":"https://www.tjh.com.cn/channels/1008.html"},{"label":"TA-BSM for obstructive HCM: Lessons Learned After the Learning Curve Period","url":"https://doi.org/10.1161/CIRCINTERVENTIONS.124.015044"},{"label":"View expertise and research →","url":"https://hub.bookimed.com/heart-surgery/doctor-xiang-wei/"},{"label":"Portrait source ↗","url":"https://providers.clevelandclinic.org/provider/nicholas-smedira/4268212"},{"label":"Nicholas Smedira →","url":"https://hub.bookimed.com/heart-surgery/doctor-nicholas-smedira/"},{"label":"Cleveland Clinic →","url":"https://hub.bookimed.com/heart-surgery/clinic-cleveland/"},{"label":"Nicholas Smedira, MD — Cleveland Clinic","url":"https://providers.clevelandclinic.org/provider/nicholas-smedira/4268212"},{"label":"Surgical management of LVOT obstruction in a specialized HOCM center","url":"https://doi.org/10.1016/j.jtcvs.2018.11.148"},{"label":"View expertise and research →","url":"https://hub.bookimed.com/heart-surgery/doctor-nicholas-smedira/"},{"label":"Browse the full specialist directory →","url":"https://hub.bookimed.com/heart-surgery/septal-myectomy-surgeons/"}]}],"introduction":"Heart surgery guide / HCM & myectomy HCM & myectomy · Decision guide Septal myectomy for obstructive HCM: compare treatment options Medicines, myectomy, septal ablation—and the team that can explain the difference. Research by Yevhenii Kozlov · Co-Founder of Bookimed Updated 8 October 2026 Sources linked throughout At a glance Septal myectomy removes selected thickened heart muscle to relieve obstruction in symptomatic HCM. The operation can also address contributing mitral or supporting structures. HCM care and rhythm-risk assessment continue after obstruction is treated. 50 mmHg is a decision threshold A resting or provoked LVOT gradient of at least 50 mmHg supports advanced-treatment assessment when symptoms persist; the number alone is not an indication for surgery. Sources: 2024 HCM guideline: official teaching slides 100 patients in the MESM study The Zhejiang series reported mean outflow gradient falling from 85.8 to 8.4 mmHg through a 4–5 cm underarm incision. Sources: Minimally Invasive Electro Septal Myectomy for HOCM Through a Right Infra-Axillary Incision $25,000–40,000 Cui programme budget Estimated programme cost of $25,000–40,000 USD. Cleveland and NYU provide individual quotations.","related_documents":[{"id":"heart-surgery","title":"Heart surgery abroad: treatments, clinics and costs","kind":"home","url":"https://hub.bookimed.com/heart-surgery/","json_url":"https://hub.bookimed.com/wp-content/uploads/heart-surgery-hub-20261007/pages/heart-surgery.json"},{"id":"minimally-invasive","title":"Minimally invasive and robotic heart surgery","kind":"guide","url":"https://hub.bookimed.com/heart-surgery/minimally-invasive/","json_url":"https://hub.bookimed.com/wp-content/uploads/heart-surgery-hub-20261007/pages/minimally-invasive.json"},{"id":"clinics","title":"Heart surgery clinics: compare techniques and specialist teams","kind":"directory","url":"https://hub.bookimed.com/heart-surgery/clinics/","json_url":"https://hub.bookimed.com/wp-content/uploads/heart-surgery-hub-20261007/pages/clinics.json"},{"id":"surgeons","title":"Find cardiac surgeons and heart specialists by procedure","kind":"surgeons","url":"https://hub.bookimed.com/heart-surgery/surgeons/","json_url":"https://hub.bookimed.com/wp-content/uploads/heart-surgery-hub-20261007/pages/surgeons.json"},{"id":"cost","title":"Heart surgery costs: valve surgery and CABG quotes","kind":"guide","url":"https://hub.bookimed.com/heart-surgery/cost/","json_url":"https://hub.bookimed.com/wp-content/uploads/heart-surgery-hub-20261007/pages/cost.json"},{"id":"recovery","title":"Recovery after heart surgery: hospital, home and travel","kind":"guide","url":"https://hub.bookimed.com/heart-surgery/recovery/","json_url":"https://hub.bookimed.com/wp-content/uploads/heart-surgery-hub-20261007/pages/recovery.json"},{"id":"second-opinion","title":"Prepare for a heart surgery second opinion","kind":"inquiry","url":"https://hub.bookimed.com/heart-surgery/second-opinion/","json_url":"https://hub.bookimed.com/wp-content/uploads/heart-surgery-hub-20261007/pages/second-opinion.json"},{"id":"latent-obstructive-hcm","title":"Latent obstructive HCM: exercise gradients, SAM and surgery","kind":"guide","url":"https://hub.bookimed.com/heart-surgery/latent-obstructive-hcm/","json_url":"https://hub.bookimed.com/wp-content/uploads/heart-surgery-hub-20261007/pages/latent-obstructive-hcm.json"},{"id":"nonobstructive-apical-hcm","title":"Nonobstructive and apical HCM: treatment decisions","kind":"guide","url":"https://hub.bookimed.com/heart-surgery/nonobstructive-apical-hcm/","json_url":"https://hub.bookimed.com/wp-content/uploads/heart-surgery-hub-20261007/pages/nonobstructive-apical-hcm.json"},{"id":"doctor-yong-cui","title":"Yong Cui: septal myectomy and minimally invasive HCM surgery","kind":"doctor-profile","url":"https://hub.bookimed.com/heart-surgery/doctor-yong-cui/","json_url":"https://hub.bookimed.com/wp-content/uploads/heart-surgery-hub-20261007/pages/doctor-yong-cui.json"},{"id":"doctor-nicholas-smedira","title":"Nicholas Smedira: septal myectomy at Cleveland Clinic","kind":"doctor-profile","url":"https://hub.bookimed.com/heart-surgery/doctor-nicholas-smedira/","json_url":"https://hub.bookimed.com/wp-content/uploads/heart-surgery-hub-20261007/pages/doctor-nicholas-smedira.json"},{"id":"doctor-paolo-ferrazzi","title":"Paolo Ferrazzi: HCM myectomy and mitral chordal cutting","kind":"doctor-profile","url":"https://hub.bookimed.com/heart-surgery/doctor-paolo-ferrazzi/","json_url":"https://hub.bookimed.com/wp-content/uploads/heart-surgery-hub-20261007/pages/doctor-paolo-ferrazzi.json"},{"id":"doctor-daniel-swistel","title":"Daniel G. 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